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So far, there are limited data available on the risk this poses to both fetuses, newborns, and mothers, but data from administering high dosages (50 and 150 mg/kg

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Because this is a once-weekly combination, accuracy, rotation and a consistent dosing day matter more than speed

Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]